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Publications related with the  Differentiation and Apoptosis inducing Therapy


1. Hiçsönmez G. Short-Course High-Dose Methylprednisolone Induces Differentiation and Apoptosis

of Myeloid Leukemic Cells. Int J Stem Cell Res Ther 2016, 3(2):033. 

2. Hiçsönmez G. Differentiation and Apoptosis inducing Therapy with High-dose Methylprednisolone  

for non- APL  Acute Myeloblastic Leukemia.  J J Bone Stem Res. 2015,1(2):007. Review

3. Hiçsönmez G. High-dose glucocorticoid for the treatment of myeloid sarcoma.  Journal of Leukemia  

2013;1:103 doi: 10.4172/2329-6917.1000103 Review

4. Hiçsönmez G.  A novel approach to treatment in  childhood acute myeloblastic leukemia and 

myelodysplastic  syndrome with high-dose methylprednisolone as a differentiation- and apoptosis 

–inducing agent of myeloid leukemic  cells. Turk J Hematol. 2010;27(1):1-7. Review

5. Hiçsönmez G. The effect of steroid on myeloid leukemic cells: The potential of short-course high-

dose methylprednisolone  treatment in inducing differentiation, apoptosis and in stimulatling 

myelopoiesis.  Leuk  Res. 2006; 30(1):60-68. Review

6. Hiçsönmez G, Çetin M, Tuncer AM, Yenicesu I, Aslan D, Özyürek E, Ünal S.  Children with acute 

myeloblastic leukemia presenting with extramedullary infiltration: the effects of high-dose steroid 

treatment.  Leuk Res. 2004;28(1):25-34.

7. Hiçsönmez G, Çetin M, Okur H, Erdemli E, Gürgey A. The potential effect of short-course high-dose 

steroid on the maturation and apoptosis of leukemic cells in a child with acute megakaryoblastic 

leukemia.  Leuk Lymphoma. 2003;44(6):1037-42.

8. Hiçsönmez G,Çetin M, Aslan D, Özyürek E. The role of short-course of high-dose 

methylprednisolone in children with acute myeloblastic leukemia (FAB M2) presented with myeloid 

tumor.  Pediatr Hematol Oncol  2003;20:73-9. 

9. Hiçsönmez G. Retinoic acid and steroid in acute promyelocytic leukemia.  Leukemia. 

2003;17(6):1203. Letter

10. Hiçsönmez G, Cetin M, Yenicesu I, Olcay L, Koç A, Aktaş D, Tunçbilek E, Tuncer M.  Evaluation of 

children with myelodysplastic syndrome: importance of extramedullary disease as a presenting 

symptom.  Leuk Lymphoma. 2001;42(4):665-74.

11. Hiçsönmez G, Tunç B, Olcay L, Tuncer MA. Effect of short-course, high-dose steroid therapy in a 

child with myelodysplastic syndrome.  Pediatr Hematol Oncol. 2001;18(8):525-9.

12. Hiçsönmez G. A novel approach to treatment with high dose steroid as a differentiation inducer 

in children with acute myeloblastic leukemia.  Pediatric Pathology and moleculer medicine. 

2000;19:251-9. Review

13. Hiçsönmez G, Tuncer M, Toksoy HB, Yenicesu I, Cetin M.  Differentiation of leukemic cells induced 

by short-course high-dose methylprednisolone in children with different subtypes of acute 

myeloblastic leukemia.  Leuk Lymphoma. 1999;33(5-6):573-80.

14. Özbek N, Erdemli E, Hiçsönmez G, Okur H, Tekelioğlu M. Effects of methylprednisolone on human 

myeloid leukemic cells in vitro.  Am J Hematol. 1999;60(4):255-9.

15. Hiçsönmez G, çetin M, Tunç B, Tuncer AM, Gümrük F, Yenicesu I. Dramatic resolution of pleural 

effusion in children with chronic myelomonocytic leukemia following short-course high-dose 

methylprednisolone.  Leuk Lymphoma. 1998 ;29(5-6):617-23.

16. Hiçsönmez G, Gümrük F, Zamani PV, Tuncer MA, Yetgin S, Gürgey A, Atahan L, Özsoylu S.  High-

dose methylprednisolone for children with acute lymphoblastic leukemia and unfavorable presenting 

features.  Eur J Haematol. 1997;58(1):26-31.

17. Hiçsönmez G.  Effects of steroids on acute myeloblastic leukaemia.  Br J Haematol. 

1996;95(1):215-6. Letter

18. Hiçsönmez G, Erdemli E, Tekelioglu M, Tuncer AM, Özbek N, Cetin M, Cotter TG. Morphologic 

evidence of apoptosis in childhood acute myeloblastic leukemia treated with high-dose 

methylprednisolone.  Leuk Lymphoma. 1996 ;22(1-2):91-6.

19. Hiçsönmez G, Özbek N, Kale G, Erdem G, Bilgiç S, Hazar V. Dramatic effect of high-dose 

methylprednisolone on orbital granulocytic sarcoma.  Pediatr Hematol Oncol. 1996;13(2):187-90.

20. Hiçsönmez G, Gümrük F.  Giant dysplastic neutrophils: possible morphologic evidence of in vivo 

differentiation of leukemia in acute myeloblastic leukemia.  Am J Hematol. 1995;49(2):168-70. Letter

21. Hiçsönmez G, Tuncer AM, Cetin M, Özbek N,Gümrük F. Eight year experiences with high-dose 

methylprednisolone as a differentation inducer in childhood acute myeloblastic leukemia (AML). 

Challenges of Modern medicine.  Differentiation therapy. 1995;10:471-5.

22. Hiçsönmez G, Cetin M, Tuncer MA, Gümrük F, Ozbek N, Kara A, Gürgey A. High-dose 

methylprednisolone for remission induction in hypoplastic acute myeloid leukemia.  Eur J Haematol. 


23. Hiçsönmez G, Tuncer AM, Sayli T, Güler E, Çetin M, Ozbek N, Mufti GJ. High-dose 

methylprednisolone, low-dose cytosine arabinoside, and mitoxantrone in children with 

myelodysplastic syndromes.  Hematol Pathol. 1995;9(3-4):185-93.

24. Hiçsönmez G, Tuncer AM, Güler E, Tan E, Tekelioglu M. The potential role of high-dose 

methylprednisolone on the maturation of leukemic cells in children with acute promyelocytic 

leukemia (APL).  Exp Hematol. 1993;21(5):599-601.

25. Hiçsönmez G, Tuncer AM, Cetin M, Gümrük F, Kara A, Yalçin S.  Morphologic evidence of in vivo 

differentiation in acute myeloblastic leukemia.  Acta Haematol. 1993;90(4):214-5. Letter

26. Hiçsönmez G, Karadeniz N, Zamani VP, Tuncer AM, Gümrük F, Erturk G, Gurgey A, Özsoylu S.  High 

remission rate in acute myeloblastic leukemia in children treated with high-dose 

methylprednisolone.  Eur J Haematol. 1992;48(4):215-20. 

27. Hiçsönmez G, Ozsoylu S, Tuncer AM, Ertürk G, Ozbek N, Karadeniz N.  Direct morphological 

evidence of high-dose methylprednisolone-induced maturation of leukemic cells in children with 

acute nonlymphoblastic leukemia.  Exp Hematol. 1991;19(3):232-3.

28. Hicsonmez G, Ozsoylu S, Tuncer AM.  Differentiation of myeloid leukemic cells induced by high-

dose methylprednisolone in patients with acute myeloblastic leukemia and its therapeutic potential. 

Leuk Res. 1991;15(7):537-41. Review.

29. Hiçsönmez G, Özsoylu S.  High-dose methylprednisolone in children with acute nonlymphoblastic 

leukemia.  Am J Hematol. 1990;35(4):288-9. Letter

30. Hiçsönmez G, Özsoylu S, Gürgey A, Zamani VP, Irken G. High-dose methylprednisolone for 

remission induction in children with acute nonlymphoblastic leukemia.  Eur J Haematol. 


31. Hiçsönmez G, Ozsoylu S.  High-dose methylprednisolone for acute nonlymphoblastic leukemia. 

Exp Hematol. 1989;17(10):1051-2. Letter

32. Hiçsönmez G, Ozsoylu S, Tuncer M, Erer B. High-dose intravenous methylprednisolone in the 

treatment of acute nonlymphoblastic leukemia  with ocular involvement.  Turk J Pediatr. 1988; 


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